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Updated: Nov 12, 2025

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Chickens productivity selection affects immune system genes.

А М Borodin1, Ya I Alekseev2, K E Gerasimov3

  • 1Breeding and Genetic Center "Smena", Bereznyaki, Moscow Region, Russia Institute of Medical and Biological Research, Nizhnii Novgorod, Russia.

Vavilovskii Zhurnal Genetiki I Selektsii
|March 19, 2021
PubMed
Summary
This summary is machine-generated.

Artificial selection for economic traits in chickens may be reducing immune system variability, potentially decreasing disease resistance. Further research aims to mitigate these negative impacts and develop disease-resistant breeds.

Keywords:
allele fixationchickens immune system genesnegative selection

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Area of Science:

  • Animal Genomics
  • Immunogenetics
  • Quantitative Genetics

Background:

  • Marker-assisted selection aims to enhance disease resistance in chickens by identifying quantitative trait loci (QTLs) linked to immune properties.
  • An unusual genotype frequency of the RACK1 gene allele (SNP Gga_rs15788101) was observed in the Smena 8 broiler line, suggesting its involvement in selection.

Purpose of the Study:

  • To investigate polymorphisms in three genes (DMA, RACK1, and CD1B) associated with the immunoglobulin Y (IgY) titer in chickens.
  • To determine if observed allele fixation in the DMA, RACK1, and CD1B genes in the Smena 8 broiler line is a result of artificial selection.

Main Methods:

  • Molecular typing of single nucleotide polymorphisms (SNPs) in the DMA, RACK1, and CD1B genes.
  • Haplotype analysis to assess linkage disequilibrium among the studied genes.
  • Comparative analysis of allele frequencies in broiler (Smena 8) and layer (Hisex White) chicken breeds.
  • Analysis of protein-coding sequences for negative selection.

Main Results:

  • Evidence of allele fixation for the unfavorable DMA and RACK1 alleles, and prevalence of the favorable CD1B allele in the Smena 8 broiler line.
  • Strong linkage disequilibrium observed among the DMA, RACK1, and CD1B genes, indicating selection pressure.
  • Allele frequencies for CD1B and RACK1 differed between Smena 8 broilers and Hisex White layers, suggesting line-specific selection. DMA allele fixation appeared consistent across breeds, possibly due to natural selection.

Conclusions:

  • Artificial selection for economic traits in broiler chickens may be driving allele fixation in immune-related genes (DMA, RACK1, CD1B), potentially reducing immune variability.
  • This reduction in genetic diversity within the immune system can compromise disease resistance.
  • Understanding the impact of selection on immunity is crucial for developing strategies to maintain or enhance disease resistance in poultry.