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SARS-CoV-2 as an inflammatory cardiovascular disease: current knowledge and future challenges
Kevin S Shah1, Mary Elizabeth Hale Hammond2, Stavros G Drakos1,3
1Division of Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
Future Cardiology
|March 19, 2021
Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, leading to various cardiovascular issues. This review covers COVID-19
Area of Science:
- Cardiology
- Infectious Diseases
- Pathophysiology
Background:
- The COVID-19 pandemic, caused by SARS-CoV-2, has presented numerous cardiovascular complications.
- SARS-CoV-2 infection can trigger inflammatory cardiovascular disease through ACE2 receptor interaction and macrophage activation syndrome in severe cases.
Purpose of the Study:
- To review the cardiovascular manifestations associated with COVID-19.
- To discuss ongoing investigations into therapeutics for COVID-19 related cardiovascular conditions.
- To explore potential long-term cardiovascular sequelae and knowledge gaps.
Main Methods:
- Literature review of cardiovascular manifestations in COVID-19 patients.
- Analysis of reported therapeutic strategies under investigation.
- Discussion of pathophysiological links between acute cardiac injury, inflammation, and chronic conditions.
Main Results:
- Multiple cardiovascular manifestations are reported in COVID-19 patients.
- SARS-CoV-2 impacts cardiovascular health via ACE2 and macrophage activation.
- Potential long-term cardiovascular effects and knowledge gaps are identified.
Conclusions:
- Understanding the cardiovascular impact of COVID-19 is crucial.
- Further research is needed to address pathophysiological links and long-term sequelae.
- Investigational efforts may advance treatments for heart failure and cardiac recovery.
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