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Interprofessional Medication Adherence Program for Patients With Diabetic Kidney Disease: Protocol for a Randomized
Carole Bandiera1,2,3, Jennifer Dotta-Celio3, Isabella Locatelli3
1School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
JMIR Research Protocols
|March 19, 2021
Summary
This study investigates how long medication adherence programs impact diabetic kidney disease (DKD) patients. Longer programs may improve adherence and clinical outcomes, crucial for managing this complex condition.
Area of Science:
- Nephrology
- Pharmacology
- Clinical Pharmacy
Background:
- Diabetic kidney disease (DKD) affects over 30% of diabetes patients, presenting complex multifactorial care challenges.
- Suboptimal medication adherence is common in DKD, negatively impacting patient outcomes.
- Structured medication adherence programs are vital for improving self-management and clinical success in DKD.
Purpose of the Study:
- To determine the impact of medication adherence program duration on long-term adherence and clinical outcomes in DKD patients.
- To evaluate the effectiveness of a pharmacist-led, interdisciplinary support program for medication adherence.
Main Methods:
- A monocentric study randomizing 73 DKD patients into 6-month and 12-month adherence programs.
- Utilizing electronic monitors for medication adherence tracking and motivational interviews.
- Assessing adherence through electronic monitors, pill counts, persistence, and implementation using generalized estimating equation multimodeling.
Main Results:
- Patient recruitment occurred from April 2016 to October 2020, with 73 participants enrolled out of 275 eligible patients.
- Data collection is ongoing; analysis is planned for 2022.
- The study protocol received ethics approval and has undergone amendments.
Conclusions:
- The PANDIA-IRIS study will offer critical insights into the influence of medication adherence program duration on adherence and clinical outcomes in DKD.
- Monitoring adherence post-intervention is innovative, providing data on the long-term effects of intervention duration.
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