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Published on: December 7, 2014
Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications
Xiuxiu Wang1, Xiaoyue Shen1, Yuting Yan1
1Provincial Key Laboratory of Biotechnology of Shaanxi, College of Life Sciences, Northwest University, Taibai North Rd 229, Xi'an, Shaanxi Province 710069, China.
Abstract:
Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it further links glycolysis with the tricarboxylic acid cycle and ATP generation. This review seeks to elucidate the regulation of PDK activity in different species, mainly mammals, and the role of PDK inhibitors in preventing increased blood glucose, reducing injury caused by myocardial ischemia, and inducing apoptosis of tumor cells. Regulations of PDKs expression or activity represent a very promising approach for treatment of metabolic diseases including diabetes, heart failure, and cancer. The future research and development could be more focused on the biochemical understanding of the diseases, which would help understand the cellular energy metabolism and its regulation by pharmacological effectors of PDKs.
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