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Related Concept Videos

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Related Experiment Video

Updated: Nov 12, 2025

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
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Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

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[Osteoporosis treatment].

Marie-Charlotte Trojani1, Véronique Breuil2

  • 1Université Côte d'Azur (UCA), service de rhumatologie, CHU de Nice, hôpital Pasteur, Nice, France.

La Revue Du Praticien
|March 19, 2021
PubMed
Summary
This summary is machine-generated.

Effective osteoporosis treatment combines lifestyle changes and medications like teriparatide, raloxifene, bisphosphonates, and denosumab. Patient education on risks, benefits, and adherence is crucial for managing this public health issue.

Keywords:
Osteoporosis

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Area of Science:

  • Endocrinology
  • Geriatrics
  • Public Health

Background:

  • Osteoporosis is a significant public health concern requiring multifaceted management strategies.
  • Effective treatment necessitates integrating pharmacological interventions with essential lifestyle modifications such as nutrition and fall prevention.

Purpose of the Study:

  • To outline a comprehensive approach to osteoporosis treatment.
  • To detail current pharmacological options and their specific indications and precautions.

Main Methods:

  • Review of current pharmacological treatments for osteoporosis, including teriparatide, raloxifene, bisphosphonates, and denosumab.
  • Emphasis on lifestyle measures, patient education, and monitoring treatment adherence and tolerance.

Main Results:

  • Specific drug recommendations based on fracture history and patient demographics (e.g., zoledronic acid post-femoral neck fracture, raloxifene for women <70).
  • Highlighting the necessity of dental precautions with denosumab and consolidation therapy post-discontinuation of certain treatments.
  • Underscoring the importance of informed patient consent regarding treatment benefits, risks, and duration.

Conclusions:

  • A comprehensive, individualized treatment plan combining pharmacotherapy and lifestyle interventions is essential for managing osteoporosis.
  • Continuous monitoring of adherence and tolerance is critical for optimizing treatment efficacy and patient outcomes.