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Janus Nanoparticles: From Fabrication to (Bio)Applications.

Xuan Zhang1, Qinrui Fu1, Hongwei Duan2

  • 1MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, P.R. China.

ACS Nano
|March 19, 2021
PubMed
Summary

Janus nanoparticles (JNPs) offer unique asymmetric structures for diverse applications. This review details their fabrication methods and highlights advancements in areas like nanomotors and biomedical uses.

Keywords:
Janus nanoparticlesbioimagingbiosensingcancermicro/nanomotorsnanostructuresself-assemblytheranostics

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemistry

Background:

  • Janus nanoparticles (JNPs) integrate multiple distinct materials into a single structure.
  • Their asymmetric design enables unique properties and simultaneous synergistic functions.
  • JNPs have garnered significant research interest due to their versatility.

Purpose of the Study:

  • To comprehensively review recent progress in Janus nanoparticle fabrication and applications.
  • To classify existing Janus nanoparticle composite types.
  • To outline current and potential future research directions.

Main Methods:

  • Classification into polymeric, inorganic, and hybrid composites.
  • Summary of fabrication strategies including self-assembly, phase separation, microfluidics, and nucleation growth.
  • Review of applications in surfactants, micro/nanomotors, and biomedicine.

Main Results:

  • Detailed overview of diverse JNP fabrication techniques.
  • Exploration of JNPs in solid surfactants, micro/nanomotors, and advanced biomedical applications.
  • Identification of key areas including biosensing, drug delivery, bioimaging, cancer therapy, and theranostics.

Conclusions:

  • Janus nanoparticles represent a rapidly advancing field with significant potential.
  • Fabrication strategies are diverse, enabling tailored nanoparticle properties.
  • Broad applications span materials science and medicine, with ongoing challenges and future opportunities.