Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Increased capillary vulnerability in diabetic retinopathy].

U Fuchs1, W Tinius, S Gonschorek

  • 1Augenklinik der Karl-Marx-Universität Leipzig.

Klinische Monatsblatter Fur Augenheilkunde
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-Range Transverse-Momentum Correlations and Radial Flow in Pb-Pb Collisions at the LHC.

Physical review letters·2026
Same author

Search for Quasiparticle Scattering in the Quark-Gluon Plasma with Jet Splittings in pp and Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2025
Same author

First Measurement of A=4 Hypernuclei and Antihypernuclei at the LHC.

Physical review letters·2025
Same author

Probing Strangeness Hadronization with Event-by-Event Production of Multistrange Hadrons.

Physical review letters·2025
Same author

Measurements of Chemical Potentials in Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2024
Same author

Observation of Medium-Induced Yield Enhancement and Acoplanarity Broadening of Low-p_{T} Jets from Measurements in pp and Central Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2024

Diabetic retinopathy patients show increased retinal capillary fragility. Their retinal capillaries are more vulnerable to damage, potentially explaining bleeding and exudation in diabetic microcirculation.

Area of Science:

  • Ophthalmology
  • Diabetic Complications
  • Microcirculation Research

Context:

  • Retinal capillary integrity is crucial for vision.
  • Diabetic retinopathy is a leading cause of blindness.
  • Understanding microvascular changes in diabetes is vital.

Purpose:

  • To investigate the structural integrity of retinal capillaries in diabetes.
  • To compare capillary vulnerability in diabetic retinopathy versus controls.
  • To explore the mechanisms behind microvascular damage in diabetes.

Summary:

  • Retinal capillaries from patients with early diabetic retinopathy (stages I-II) and hypertension were isolated using trypsinization.
  • Diabetic capillaries showed earlier loss of endothelial cells and pericytes, forming cell-free basement membrane tubes compared to controls.

Related Experiment Videos

  • This indicates looser intercellular junctions and reduced cell adhesion in diabetic retinal microvasculature, increasing vulnerability.

    • Impact:

    • The findings highlight increased retinal capillary vulnerability in diabetes, contributing to bleeding and exudation.
    • This research provides insights into the pathogenesis of diabetic retinopathy.
    • Further studies are needed to determine if this damage occurs in vivo or is unmasked in vitro.