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Related Experiment Video

Updated: Nov 12, 2025

Preparing Lamellae from Vitreous Biological Samples Using a Dual-Beam Scanning Electron Microscope for Cryo-Electron Tomography
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Annulate lamellae and intracellular pathogens.

Sébastien Eymieux1,2, Emmanuelle Blanchard1,2, Rustem Uzbekov2

  • 1Inserm U1259 MAVIVH, Université de Tours and CHRU de Tours, Tours, France.

Cellular Microbiology
|March 19, 2021
PubMed
Summary
This summary is machine-generated.

Annulate lamellae (AL), organelles made of endoplasmic reticulum membranes, are increasingly linked to viral infections like HCV and SARS-CoV-2. Their role in pathogen interactions and cell regulation requires further investigation.

Keywords:
annulate lamellaeelectron microscopyintracellular parasitemembranous webvirus

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Area of Science:

  • Cell Biology
  • Virology
  • Parasitology

Background:

  • Annulate lamellae (AL) are enigmatic organelles composed of stacked endoplasmic reticulum-derived membranes featuring nuclear pore complexes (NPCs).
  • Their precise function remains largely unknown, despite frequent observation in rapidly dividing cells.
  • Emerging evidence suggests a potential role for AL in viral pathogenesis.

Purpose of the Study:

  • To explore the potential involvement of Annulate Lamellae in viral life cycles.
  • To investigate the structural and functional implications of AL in host-pathogen interactions.
  • To elucidate the role of AL in cellular processes like calcium homeostasis and cell cycle control.

Main Methods:

  • Electron microscopy was used to observe AL in infected cells.
  • Analysis of viral life cycles in relation to AL presence.
  • Comparative studies of AL in cells infected with different pathogens.

Main Results:

  • AL have been observed during the early stages of Hepatitis C Virus (HCV) and SARS-CoV-2 infections.
  • The NPCs within AL may facilitate communication between cellular compartments and the cytoplasm.
  • AL were also identified in cells infected with the protozoan parasite Theileria annulata.

Conclusions:

  • Annulate lamellae appear to be induced by certain viruses and parasites, suggesting a role in infection.
  • AL's structure, particularly its NPCs, might be exploited by pathogens for replication or spread.
  • Further research is crucial to fully understand AL's function in host-pathogen dynamics and cellular regulation.