[Curcumin in the correction of oxidative and immune disorders during exercises]

Oxidative and immune dysfunctions during physical exertion can be associated with a violation of enzyme systems and antioxidant protection, the state of innate and adaptive immunity. This creates the preconditions for their pharmacological correction. The aim of this review is to summarize and analyze modern data on the role of curcumin, one of the components of the extract of turmeric rhizomes (Curcuma longa), in the correction of oxidative stress and immune disorders during physical exertion. Material and methods. When writing the review, a search has been carried out for the original articles presented in PubMed, Web of Science, Google Scholar databases, eLIBRARY.RU and CyberLeninka platforms, with a randomized controlled crossover or parallel design, in which the use of curcumin administered before and / or after exercise was compared with placebo. No filters were applied by type of exercise performed, gender or age of participants. Results. In randomized controlled trials conducted for 2008-2020, evidences were obtained that the use of complexes containing curcumin normalizes the general antioxidant status, restores quality, quantity and functional-metabolic status of immunocytes. Data from prospective epidemiological studies show that turmeric extract exhibits partial anti-inflammatory, immunotropic and antioxidant activity in vitro and in vivo, which provides a basis for further studies on the effectiveness and systemic use of turmeric long. Conclusion. The inclusion of turmeric extract in complex dietary regimens, including during physical activity, helps to prevent immune and oxidative disorders, and exert some anti-inflammatory effect.