Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Vaccines01:30

Cancer Vaccines

616
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
616
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

634
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
634
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

249
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
249
Vaccinations01:51

Vaccinations

49.1K
Overview
49.1K
Preclinical Development: Overview01:28

Preclinical Development: Overview

5.4K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell-Mediated Immunity of mRNA-1283 Vaccine Encoding SARS-CoV-2 Spike Receptor-Binding and N-Terminal Domains in Preclinical and Clinical Studies.

The Journal of infectious diseases·2026
Same author

Monovalent and multivalent OspA mRNA-LNP vaccines elicit functional antibodies and protect against Borrelia burgdorferi in mice.

NPJ vaccines·2026
Same author

Predictive modeling of immune escape and antigenic grouping of SARS-CoV-2 variants.

Journal of virology·2026
Same author

Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques.

Immunity·2026
Same author

Maternal expression and breast milk transfer of an mRNA- encoded monoclonal antibody in a murine model of cholera.

PLoS neglected tropical diseases·2026
Same author

Harnessing mRNA for the expression of monoclonal IgG and IgA in non-human primates.

Frontiers in immunology·2026
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
See all related articles

Related Experiment Video

Updated: Nov 12, 2025

Efficient Transfection of In vitro Transcribed mRNA in Cultured Cells Using Peptide-Poloxamine Nanoparticles
10:16

Efficient Transfection of In vitro Transcribed mRNA in Cultured Cells Using Peptide-Poloxamine Nanoparticles

Published on: August 17, 2022

3.6K

Novel approaches for vaccine development.

Makda S Gebre1, Luis A Brito2, Lisa H Tostanoski3

  • 1Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

Cell
|March 19, 2021
PubMed
Summary
This summary is machine-generated.

Novel vaccines like RNA and viral vector platforms address limitations of traditional vaccines for challenging pathogens. Advances in biomaterials and engineering further enhance vaccine development for global health security.

More Related Videos

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes
08:27

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

4.8K
Expression and Purification of Virus-like Particles for Vaccination
06:17

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

22.4K

Related Experiment Videos

Last Updated: Nov 12, 2025

Efficient Transfection of In vitro Transcribed mRNA in Cultured Cells Using Peptide-Poloxamine Nanoparticles
10:16

Efficient Transfection of In vitro Transcribed mRNA in Cultured Cells Using Peptide-Poloxamine Nanoparticles

Published on: August 17, 2022

3.6K
Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes
08:27

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

4.8K
Expression and Purification of Virus-like Particles for Vaccination
06:17

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

22.4K

Area of Science:

  • Vaccinology
  • Biotechnology
  • Infectious Disease Research

Background:

  • Traditional vaccines are vital but face challenges with persistent, rapidly evolving, or novel pathogens.
  • Existing vaccine technologies struggle with complex antigens and emerging infectious disease threats.

Purpose of the Study:

  • To review the current status of novel vaccine technologies.
  • To highlight advances in RNA, viral vector, biomaterials, and engineering for vaccine development.

Main Methods:

  • Review of current literature on nucleic acid vaccines (RNA).
  • Review of current literature on viral vector vaccines (adenovirus).
  • Discussion of advances in biomaterials and engineering relevant to vaccine development.

Main Results:

  • Novel vaccine platforms show promise for overcoming limitations of traditional approaches.
  • RNA and viral vector vaccines are well-suited for challenging pathogens.
  • Biomaterials and engineering offer new strategies to improve vaccine efficacy and delivery.

Conclusions:

  • Novel vaccine technologies represent a significant advancement in addressing unmet public health needs.
  • Continued research in RNA, viral vectors, biomaterials, and engineering is crucial for future vaccine innovation.
  • These technologies have the potential to revolutionize vaccine development and improve global health outcomes.