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Related Experiment Video

Updated: Nov 12, 2025

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
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Sampling trabecular meshwork using TrabEx.

Vipul Ramjiani1, Hardeep-Singh Mudhar2, Thomas Julian3,4

  • 1Department of Ophthalmology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Rd, England, S10 2JF, Sheffield, UK. vipul.ramjiani@nhs.net.

BMC Ophthalmology
|March 20, 2021
PubMed
Summary
This summary is machine-generated.

The TrabEx+ device successfully sampled trabecular meshwork tissue, preserving its architecture for glaucoma research. This method allows for detailed histopathological analysis of glaucomatous features.

Keywords:
Ab interno trabeculectomyHistologyTissue samplingTrabEx+Trabecular meshwork

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Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Surgical Innovation

Background:

  • Trabecular meshwork sampling is crucial for understanding glaucoma.
  • Ab interno trabeculectomy offers a minimally invasive approach.
  • Assessing trabecular meshwork architecture aids in glaucoma diagnosis and progression monitoring.

Purpose of the Study:

  • To evaluate the TrabEx+ device for ab interno trabeculectomy.
  • To assess the preservation of trabecular meshwork architecture in retrieved samples.
  • To determine the suitability of samples for histopathological analysis of glaucomatous features.

Main Methods:

  • Six glaucomatous eyes underwent ab interno trabeculectomy using the TrabEx+ device.
  • Trabecular meshwork samples were excised and retrieved.
  • Samples were processed and stained for histopathological examination, including immunohistochemistry for Collagen IV.

Main Results:

  • Trabecular meshwork was successfully sampled in five out of six cases.
  • Histological analysis confirmed the presence of trabecular beams and cells with preserved lamellar structure.
  • Basement membrane was identifiable in some specimens, indicating successful tissue preservation.

Conclusions:

  • The TrabEx+ device enables successful retrieval of trabecular meshwork samples.
  • The retrieved samples exhibit sufficient architectural integrity for histopathological analysis.
  • This technique supports further research into glaucoma pathophysiology and diagnosis.