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A technical note on contamination from PRF tubes containing silica and silicone.
Richard J Miron1, Tomoyuki Kawase2, Anika Dham3
1Department of Periodontology, University of Bern, Bern, Switzerland. richard.miron@zmk.unibe.ch.
BMC Oral Health
|March 20, 2021
Summary
Many PRF tubes contain chemical additives like silica, impacting tissue regeneration. Using plain, chemical-free tubes optimizes PRF clot formation and reduces inflammation for better clinical outcomes.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Dental Innovations
Background:
- Platelet-rich fibrin (PRF) accelerates tissue regeneration via neoangiogenesis.
- PRF offers advantages over traditional platelet-rich plasma (PRP) by avoiding chemical additives.
- Clinicians often lack awareness that PRF tubes may contain undisclosed chemical additives.
Purpose of the Study:
- To provide a technical note on recent discoveries concerning PRF tubes.
- To describe research trends on PRF tube additives from the authors' laboratories.
- To highlight the impact of tube additives on PRF production and clinical outcomes.
Main Methods:
- Review of literature on additives in PRF tubes, primarily silica and silicone.
- Analysis of studies investigating the effects of these additives.
- Presentation of recommendations for optimizing PRF clots and membranes.
Main Results:
- PRF production is optimal with plain, chemical-free glass tubes.
- Non-standard tubes (e.g., for lab diagnostics) can lead to unpredictable PRF outcomes.
- Observed issues include variable clot size, delayed clot formation, and increased inflammation.
Conclusions:
- Selecting appropriate centrifugation tubes is crucial for PRF production.
- Silica/silicone additives negatively affect clot formation, cell behavior, and in vivo inflammation.
- Further research emphasizes the importance of chemical-free tubes for predictable PRF efficacy.
