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Brain/MINDS beyond human brain MRI project: A protocol for multi-level harmonization across brain disorders
Shinsuke Koike1, Saori C Tanaka2, Tomohisa Okada3
1Center for Evolutionary Cognitive Sciences (ECS), Graduate School of Art and Sciences, The University of Tokyo, Meguro-ku, Tokyo 153-8902, Japan; University of Tokyo Institute for Diversity & Adaptation of Human Mind (UTIDAHM), Meguro-ku, Tokyo 153-8902, Japan; University of Tokyo Center for Integrative Science of Human Behavior (CiSHuB), 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan; The International Research Center for Neurointelligence (WPI-IRCN), Institutes for Advanced Study (UTIAS), University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan.
The Brain/MINDS Beyond project aims to create reliable brain imaging biomarkers for neurological and psychiatric disorders. By harmonizing data across multiple sites, it seeks to improve diagnosis and treatment across the lifespan.
Area of Science:
- Neuroimaging
- Biomarker Discovery
- Brain Disorders
Background:
- Established brain imaging biomarkers for psychiatric and neurological disorders are lacking.
- Current magnetic resonance imaging (MRI) studies face challenges in diagnostic and therapeutic application.
- Lifespan brain research requires standardized, multi-site data collection and analysis.
Purpose of the Study:
- To establish clinically-relevant, harmonized imaging biomarkers for brain disorders.
- To develop and validate a multi-site data collection and analysis protocol.
- To facilitate the identification of disease-specific pathophysiology across the lifespan.
Main Methods:
- Implementation of the Harmonization Protocol (HARP) across 13 research sites using 3T MRI scanners.
- Collection of multimodal brain imaging data (T1/T2-weighted, functional MRI, diffusion MRI) from healthy traveling subjects and patients.
- Preprocessing and analysis of neuroimaging data utilizing Human Connectome Project methodologies.
Main Results:
- Preliminary results show comparable cortical thickness, myelin, and functional connectivity measures across 5 scanners.
- Demonstrated sensitivity of the protocol to subject-specific connectome variations.
- Successful harmonization of multi-site data from healthy traveling subjects.
Conclusions:
- The Brain/MINDS Beyond project is pioneering a prospective, multi-level harmonization protocol for multi-site brain MRI data.
- The established protocols and forthcoming data will aid in identifying disease-specific pathophysiology and imaging biomarkers.
- This initiative holds significant potential for advancing clinical practice in diagnosing and treating intractable brain disorders across the lifespan.
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