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Updated: Nov 12, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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Efficient synthesis of 5-(hydroxymethyl)piperazin-2-ones using automatically prepared chiral bromocarboxylic acid and

Hisashi Masui1, Kohei Naito2, Mai Minoshima2

  • 1Department of Pharmaceutical Sciences, Yokohama University of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama 245-0066, Japan; Graduate School of Pharmaceutical Sciences, Department of Basic Medicinal Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.

Bioorganic & Medicinal Chemistry Letters
|March 20, 2021
PubMed

Keywords:
Amino acid analogsAutomated synthesisHeterocyclesPiperazioneα-Bromocarboxylic acid

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