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Updated: Nov 12, 2025

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

Resilient three-dimensional ordered architectures assembled from nanoparticles by DNA.

Pawel W Majewski^1,2, Aaron Michelson³, Marco A L Cordeiro¹

¹Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY 11973, USA.

Science Advances

|March 20, 2021

Summary

This summary is machine-generated.

Researchers created robust silica replicas of DNA-nanoparticle structures. These durable nanomaterials maintain nanoparticle organization under extreme conditions, expanding applications for advanced materials.

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Area of Science:

Materials Science
Nanotechnology
Biomaterials Engineering

Background:

DNA-based assembly enables precise 3D organization of nanoparticles into complex nanomaterials.
Current DNA-nanoparticle constructs face limitations due to the narrow stability range of DNA lattices.
Applications in optics, catalysis, and mechanics are hindered by the environmental sensitivity of DNA-NP materials.

Purpose of the Study:

To develop a method for creating stable, inorganic replicas of 3D DNA-nanoparticle structures.
To overcome the environmental stability limitations of DNA-based nanomaterials.
To enable the use of DNA assembly strategies for creating robust nanomaterials.

Main Methods:

Utilized DNA-based assembly to organize nanoparticles in 3D lattices.
Employed 3D mineralization to create silica replicas of the DNA-nanoparticle structures.
Characterized the structural integrity, porosity, and stability of the silica replicas.

Main Results:

Successfully fabricated silica replicas of 3D periodic DNA-nanoparticle structures with diverse lattice symmetries.
The silica replicas preserved the DNA-directed spatial arrangement and connectivity of nanoparticles.
The resulting silicated lattices demonstrated exceptional stability against high temperatures (>1000°C), high pressures (8 GPa), and radiation.
The materials exhibited controllable porosity and were compatible with nanolithography.

Conclusions:

The developed approach provides a pathway to robust, inorganic nanomaterials templated by DNA assembly.
These silica-DNA-nanoparticle replicas offer enhanced stability, broadening the operational conditions for DNA-assembled materials.
This method facilitates the creation of advanced nanomaterials for demanding applications by combining DNA programmability with inorganic material resilience.