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Patient-reported outcome measures for acne: a mixed-methods validation study (acne PROMs)
Samantha Hornsey1, Beth Stuart2, Ingrid Muller2
1Faculty of Medicine, Primary Care, Population Sciences and Medical Education, University of Southampton, Southampton, Hampshire, UK sh7g13@soton.ac.uk.
Two patient-reported outcome measures (PROMs) for adult acne demonstrated good validity and reliability. While both PROMs are acceptable for research, consider their specific domains when selecting for adult acne studies.
Area of Science:
- Dermatology
- Health Outcomes Research
- Psychometrics
Background:
- Adult acne significantly impacts patients' quality of life.
- Validated patient-reported outcome measures (PROMs) are crucial for assessing treatment efficacy and patient experience.
- Existing PROMs require ongoing evaluation for acceptability and validity in specific populations.
Purpose of the Study:
- To assess the acceptability and validity of two PROMs for adult acne.
- To compare these PROMs against the established Acne-specific Quality of Life (Acne-QoL) measure.
- To provide guidance on selecting appropriate PROMs for adult acne research.
Main Methods:
- A mixed-methods validation study design.
- Quantitative data collection from 204 adult acne participants using Acne-QoL, Skindex-16, and Comprehensive Acne Quality of Life Scale (CompAQ).
- Qualitative data collection through cognitive interviews with 17 participants to explore usability and acceptability.
Main Results:
- Both Skindex-16 and CompAQ exhibited high internal consistency (Cronbach's alpha 0.74-0.96) and reliability (ICC 0.88-0.97).
- Strong construct validity was observed when comparing Skindex-16 and CompAQ to Acne-QoL (Spearman's rho 0.54-0.81).
- Qualitative findings revealed varied participant opinions on usability, layout, and question wording, with no single PROM demonstrating superior acceptability.
Conclusions:
- All evaluated PROMs performed well statistically, indicating their suitability for adult acne research.
- No single PROM was definitively superior in terms of usability and acceptability.
- Researchers should carefully consider the specific domains measured by each PROM (e.g., facial vs. facial and trunk acne) when making selections.
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