A single arm trial using passive simulated jogging for blunting acute hyperglycemia

Area of Science:

• Metabolic Health
• Cardiovascular Disease Prevention
• Biomedical Engineering

Background:

• Glycemic fluctuations contribute to oxidative stress, endothelial dysfunction, and cardiovascular disease.
• Reducing glycemic variability is a key therapeutic goal.
• A previously developed portable motorized passive simulated jogging device (JD) demonstrated efficacy in lowering 24-hour glycemic indices.

Purpose of the Study:

• To evaluate the effectiveness and feasibility of the JD in mitigating significant glycemic fluctuations.
• To assess the impact of JD use on glycemic response following an oral glucose tolerance test (OGTT).

Main Methods:

• Ten adult participants (mean age 41.3 ± 13.5 years) with healthy, mostly obese profiles were enrolled.
• Participants underwent an OGTT before and after a 7-day intervention period using the JD for 90 minutes daily.
• Interstitial glucose monitoring was employed, and integrated areas under the curve (iAUC) for specific time intervals (2h-4h) were calculated.

Main Results:

• Seven days of JD use significantly blunted the glycemic fluctuation induced by the OGTT.
• The JD decreased the 2-hour AUC by 17 ± 4.7% and the 4-hour iAUC by 15 ± 5.9% (p < 0.03).

Conclusions:

• The portable motorized passive simulated jogging device (JD) effectively reduces acute hyperglycemic excursions following an OGTT in healthy, predominantly obese adults.
• The JD presents a potential adjunct therapy for glycemic management, offering an alternative for individuals with limitations or reluctance towards conventional exercise.
• The device's feasibility and applicability in diverse postures support its potential use for individuals with physical or cognitive constraints.