Related Experiment Video
Updated: Nov 12, 2025
10:17
An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
Published on: April 26, 2019
7.2K
The Relationship Between Type 2 Diabetes, NAFLD, and Cardiovascular Risk
Cyrielle Caussy1, Adrien Aubin2, Rohit Loomba3,4,5
1Hôpital Lyon Sud, Département Endocrinologie, Diabète et Nutrition, Hospices Civils de Lyon, 69495, Pierre-Bénite, France. cyrielle.caussy@chu-lyon.fr.
Current Diabetes Reports
|March 20, 2021
Summary
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) significantly increase cardiovascular disease (CVD) risk. Patients with both conditions face a synergistic, heightened risk, necessitating intensive cardiovascular prevention strategies.
Area of Science:
- Hepatology
- Endocrinology
- Cardiology
Background:
- Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are prevalent conditions.
- Both NAFLD and T2DM are independently associated with an increased risk of cardiovascular disease (CVD).
Purpose of the Study:
- To review the current understanding of the association between NAFLD, T2DM, and CVD risk.
- To explore the synergistic impact of co-existing NAFLD and T2DM on cardiovascular outcomes.
- To discuss potential therapeutic strategies and the need for intensive CVD prevention.
Main Methods:
- Literature review of studies examining the relationship between NAFLD, T2DM, and CVD.
- Analysis of evidence supporting NAFLD as an independent CVD risk factor.
- Evaluation of shared pathophysiological pathways and the impact of anti-diabetic therapies.
Main Results:
- NAFLD is increasingly recognized as an independent risk factor for CVD.
- Patients with both T2DM and NAFLD exhibit a significantly higher CVD risk compared to those with T2DM alone, suggesting a synergistic effect.
- Certain anti-diabetic medications demonstrate positive effects on both NAFLD and CVD parameters.
Conclusions:
- Individuals with T2DM and NAFLD should be classified as high-risk for CVD.
- Intensified cardiovascular prevention strategies are warranted for this patient population.
- Further long-term studies are required to confirm the efficacy of NAFLD treatment in reducing CVD risk.
Related Concept Videos
01:30Coronary Artery Disease I: Introduction
633
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
633
01:36Carbohydrate Metabolism
13.0K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.0K
01:26Coronary Artery Disease II: Pathophysiology
165
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
165
01:22Diabetes Mellitus: Type 2 and Gestational
3.7K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.7K
01:26Atherosclerosis III: Management
110
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
110
01:15Diabetes: Symptoms, Diagnosis, and Complications
1.4K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.4K