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Fetal therapy using rapamycin for a rapidly enlarging, obstructive, cervical lymphatic malformation: a case report
Joel Livingston1,2, Nouf Alrowaily2,3, Philip John2,4
1Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Prenatal Diagnosis
|March 20, 2021
Summary
This study shows that in-utero rapamycin therapy is safe and effective for fetal lymphatic malformations (LMs). Early intervention with rapamycin may lead to better outcomes for severe fetal LMs.
Area of Science:
- Perinatology
- Vascular Malformations
- Pharmacology
Background:
- Fetal lymphatic malformations (LMs) are detectable via prenatal ultrasound.
- Limited therapeutic options previously existed for fetal LMs.
- Rapamycin, a mTOR inhibitor, is a recently established safe and effective therapy for pediatric LMs, with early treatment showing improved efficacy.
