Related Experiment Video
Updated: Nov 12, 2025

06:31
Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
Published on: October 3, 2019
8.9K
Patch testing in skin of color: A brief report
Shant Tamazian1, Michelle Oboite1,2, James R Treat1,2
1Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Pediatric Dermatology
|March 20, 2021
Summary
Patch testing interpretation in skin of color requires specific training. This study presents pediatric cases to aid dermatologists in recognizing positive patch tests in patients with increased skin melanin.
Area of Science:
- Dermatology
- Allergy and Immunology
- Pediatrics
Background:
- Dermatology training must equip physicians to identify skin changes in diverse populations.
- Interpreting patch tests for contact dermatitis in skin of color is challenging due to the need to visualize erythema.
- A lack of clinical images of skin of color in medical literature hinders training.
Purpose of the Study:
- To provide visual examples of patch test interpretations in pediatric patients with skin of color.
- To demonstrate an effective approach for clinical interpretation of patch testing in melanin-rich skin.
- To address the gap in educational resources for dermatologists regarding patch testing in diverse skin tones.
Main Methods:
- Case study presentation of two pediatric patients.
- Inclusion of clinical photographs illustrating patch test reactions.
- Focus on the interpretation of positive patch tests in skin of color.
Main Results:
- Demonstrated visible erythema in patch test sites on pediatric patients with skin of color.
- Provided clear visual references for identifying a 1+ positive patch test reaction.
- Highlighted the importance of considering skin tone when assessing patch test results.
Conclusions:
- Physicians need enhanced training for patch testing in skin of color.
- Clinical images are crucial for accurate interpretation of patch test results in melanin-rich skin.
- This resource aids dermatologists in diagnosing contact dermatitis in pediatric patients of all skin tones.
Related Concept Videos
Changes in Skin Color: Clinical Perspectives
2.9K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.9K
Skin Cancer
5.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.1K
Pigmentation
3.7K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
3.7K
Skin Diseases and Disorders
4.7K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.7K

