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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Thyroid function in postpartum psychosis: An exploratory study.

Rati Ranjan Sethy1, Shobit Garg2, Daya Ram3

  • 1Department of Psychiatry, IMS & Sum Hospital, Bhubaneswar, India.

Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists
|March 20, 2021
PubMed
Summary
This summary is machine-generated.

Thyroid function differs in women with postpartum onset psychosis (PPO). PPO patients showed higher FT4 levels and thyroid lobe changes, suggesting a link to postpartum psychosis.

Keywords:
postpartum psychosisthyroidultrasonography

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Area of Science:

  • Endocrinology
  • Psychiatry
  • Women's Health

Background:

  • Postpartum psychosis (PPP) is a severe mental health condition.
  • Thyroid dysfunction is common in postpartum women and can mimic psychiatric symptoms.

Purpose of the Study:

  • To compare thyroid function and thyroid lobe volume in women with postpartum onset psychosis (PPO), psychosis without postpartum onset (PWPO), and healthy postpartum controls (HC).
  • To identify potential biomarkers for PPO.

Main Methods:

  • Recruited 20 women in each of three groups: PPO, PWPO, and HC.
  • Assessed psychopathology, episode duration, thyroid function (FT4 levels), and thyroid lobe volume.

Main Results:

  • The PPO group exhibited significantly greater psychopathology and shorter episodes than the PWPO group.
  • The PPO group showed significantly greater right thyroid lobe volume compared to PWPO and HC groups.
  • The PPO group had significantly higher FT4 levels than the HC group.

Conclusions:

  • An isolated increase in FT4 levels and changes in thyroid lobe volume may be specifically associated with postpartum onset psychosis.
  • Thyroid function and morphology could serve as potential indicators for PPO.