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Updated: Nov 12, 2025
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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
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The interaction between miRNAs/lncRNAs and Notch pathway in human disorders
Soudeh Ghafouri-Fard1, Mark C Glassy2, Atefe Abak3
1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Summary
This review explores how long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) interact with the Notch pathway. These interactions are crucial in both cancer development and non-neoplastic conditions, influencing cell behavior.
Area of Science:
- Molecular Biology
- Cell Biology
- Genetics
Background:
- The Notch pathway is a critical signaling cascade regulating cell proliferation, differentiation, development, and tissue homeostasis.
- This pathway influences stem cell properties, impacting both normal development and cancer metastasis.
- Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are known regulators or targets of the Notch pathway.
Purpose of the Study:
- To illuminate the intricate interplay between lncRNAs, miRNAs, and the Notch pathway.
- To examine these interactions within the contexts of both cancer and non-neoplastic conditions.
Main Methods:
- Literature review of studies investigating lncRNA-Notch and miRNA-Notch interactions.
- Synthesis of findings on specific lncRNAs (e.g., FOXD2-AS1, HOTAIR) and miRNAs (e.g., miR-19, miR-146a) involved.
- Categorization of interactions based on their role in cancers and non-neoplastic diseases.
Main Results:
- Numerous lncRNAs, including FOXD2-AS1, MEG3, ANRIL, and HOTAIR, directly interact with the Notch signaling pathway.
- A variety of miRNAs, such as miR-19, miR-21, miR-34a, and miR-146a, functionally interplay with Notch signaling.
- These regulatory interactions are significant in both the progression of cancers and the pathophysiology of non-neoplastic conditions.
Conclusions:
- lncRNAs and miRNAs are key modulators of Notch pathway activity.
- Understanding these regulatory networks is vital for deciphering disease mechanisms in both cancer and non-neoplastic settings.
- Further research into lncRNA-miRNA-Notch axis offers potential therapeutic avenues.
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