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Tuberculosis: A persistent unpleasant neighbour of humans

Mitsuko Seki1, Hongjo Choi2, Kyungjong Kim3

  • 1Division of Pediatric Dentistry, Department of Human Development and Fostering, Meikai University School of Dentistry, 1-1, Keyakidai, Sakado, Saitama 350-0283, Japan; Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo 173-8610, Japan.

Journal of Infection and Public Health
|March 20, 2021
PubMed

Insights

Mycobacterium tuberculosis causes tuberculosis and persists due to human population growth and antimicrobial resistance. Novel strategies are needed to combat this persistent pathogen.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Mycobacterium tuberculosis (M. tuberculosis) is the causative agent of tuberculosis (TB).
  • TB transmission occurs from infected individuals, with M. tuberculosis initially remaining quiescent in new hosts.
  • The pathogen's persistence is linked to human population growth, globalization, and antimicrobial resistance.

Purpose of the Study:

  • To highlight the challenges in combating Mycobacterium tuberculosis.
  • To underscore the need for novel approaches against tuberculosis.
  • To discuss the factors contributing to the persistence of M. tuberculosis.

Main Methods:

  • This study is a review of the factors contributing to the persistence of M. tuberculosis.
  • Analysis of M. tuberculosis survival strategies, including antimicrobial resistance.
  • Examination of the role of human population dynamics and globalization in TB spread.

Main Results:

  • M. tuberculosis exhibits a quiescent phase post-transmission, delaying symptomatic infection.
  • Human population growth and global interconnectedness facilitate pathogen spread.
  • Antimicrobial resistance is a significant survival strategy for M. tuberculosis.

Conclusions:

  • Tuberculosis remains a persistent threat due to M. tuberculosis's biological and host-related factors.
  • Overcoming TB requires innovative strategies beyond current antimicrobial treatments.
  • Understanding pathogen persistence is crucial for developing effective public health interventions against TB.
Keywords:
DiagnosisM/XDR-TBResource-limited settingsTreatmentTuberculosis

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