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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Seizures: Classification01:13

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Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
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Psychosurgery01:30

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Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
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Related Experiment Video

Updated: Nov 12, 2025

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SYLVIUS: A multimodal and multidisciplinary platform for epilepsy surgery.

Alfredo Higueras-Esteban1, Ignacio Delgado-Martínez2, Laura Serrano3

  • 1Galgo Medical SL, Neurosurgery Dept, Barcelona, Spain; Universitat Pompeu Fabra, BCN Medtech, Dept. of Information and Communication Technologies, Barcelona, Spain.

Computer Methods and Programs in Biomedicine
|March 20, 2021
PubMed
Summary

SYLVIUS software streamlines epilepsy surgery by improving data flow for drug-resistant epilepsy diagnosis and treatment. It enhances surgical planning through integrated visualization and analysis, aiding clinicians in decision-making.

Keywords:
Diffusion-weighted imaging (DWI)Epilepsy surgeryMultidisciplinaryMultimodalStereotactic electroencephalography (SEEG)Surgical workflow

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Area of Science:

  • Neurosurgery
  • Medical Software Development
  • Epileptology

Background:

  • Drug-resistant epilepsies require complex diagnostic and surgical workflows.
  • Stereoencephalography (SEEG) provides crucial invasive data for surgical planning.
  • Multidisciplinary input is essential for diagnostic efficacy and surgical safety.

Purpose of the Study:

  • To introduce SYLVIUS, a software platform designed to optimize the workflow for diagnosing and surgically treating drug-resistant epilepsies.
  • To enhance data flow and decision-making across different stages of epilepsy surgery.

Main Methods:

  • SYLVIUS integrates tools for stereo visualization, data registration, electrode plan transfer, automated contact segmentation, and DWI tractography analysis.
  • A clinical workflow ensures seamless and safe patient data sharing across specialties.
  • Nineteen retrospective cases were evaluated to assess plan modifications using SYLVIUS.

Main Results:

  • The SYLVIUS software facilitated trajectory modifications in all 19 evaluated cases.
  • Integration of multimodal information within SYLVIUS led to a higher number of trajectory adjustments.
  • Modified plans were successfully imported into a robotic system for surgical intervention.

Conclusions:

  • SYLVIUS streamlines epilepsy surgery by providing a digital, multimodal 2D/3D clinical tool.
  • The platform supports collaborative definition and validation of surgical plans for SEEG cases.
  • It enhances the integration of diagnostic information for improved surgical outcomes.