Related Experiment Video
Updated: Nov 12, 2025

A Reporter Assay to Analyze Intronic microRNA Maturation in Mammalian Cells
Published on: June 16, 2022
MiR-375: A novel multifunctional regulator
Yang Liu1, Qiuyuan Wang1, Jie Wen1
1College of Life Science and Technology, Harbin Normal University, Harbin 150001, PR China.
Abstract:
MiR-375, a primitively described beta cell-specific miRNA, is confirmed to function as multi-functional regulator in diverse typical cellular pathways according to the follow-up researches. Based on the existing studies, miR-375 can regulate many functional genes and ectopic expressions of miR-375 are usually associated with pathological changes, and its expression regulation mechanism is mainly related to promoter methylation or circRNA. In this review, the regulatory functions of miR-375 in immunity, such as its relevance with macrophages, T helper cells and autoimmune diseases were briefly discussed. Also, the functions of miR-375 involved in inflammation, development and virus replication were reviewed. Finally, the mechanisms and application prospects of miR-375 in cancers were analyzed. Studies show that the application of miR-375 as therapeutic target and biomarker has a broad developing space in future. We hope this paper can provide reference for its further study.
Related Concept Videos
Master Transcription Regulators
Master Transcription Regulators
Regulation of Expression at Multiple Steps
MicroRNAs
MicroRNAs
Allosteric Regulation

