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Related Concept Videos

Meiosis II02:02

Meiosis II

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Meiosis II entails cell division and segregation of the sister chromatids, resulting in the production of four unique haploid gametes. The steps for meiosis II are similar to mitosis, except that meiosis II occurs in haploid cells, whereas mitosis occurs in diploid cells.
The timing and cell division patterns of meiosis differ between males and females. In male meiosis, the centrosomes are part of the formation of the meiotic spindle. However, in oocytes, including that of humans, Drosophila,...
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The Cell Cycle Control System01:28

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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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Meiosis I03:09

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Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
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Meiosis I01:49

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Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by...
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Cohesins02:20

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Cohesin protein complexes are a molecular glue that holds two sister chromatids together. They play an important role both in mitosis and meiosis. In mitosis, all cohesin complexes present on the chromosomes are removed before the start of the anaphase stage.
Cohesin complexes in Meiotic Division
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Updated: Nov 12, 2025

Use of Time-Lapse Microscopy and Stage-Specific Nuclear Depletion of Proteins to Study Meiosis in S. cerevisiae
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Use of Time-Lapse Microscopy and Stage-Specific Nuclear Depletion of Proteins to Study Meiosis in S. cerevisiae

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Meiotic regulation of the Ndc80 complex composition and function.

Jingxun Chen1, Elçin Ünal2

  • 1Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA.

Current Genetics
|March 21, 2021
PubMed
Summary

The Ndc80 complex

Keywords:
Chromosome segregationKinetochoreLUTIMeiosisProteolysisTranscript isoformsuORF

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • The Ndc80 complex is a crucial kinetochore component regulating chromosome segregation.
  • Its subunit abundance is vital for proper kinetochore function during meiosis.
  • Recent studies highlight Ndc80 as the limiting factor for kinetochore activation in budding yeast meiosis.

Purpose of the Study:

  • To review current models of Ndc80 complex subunit abundance regulation during meiosis.
  • To compare regulatory mechanisms in budding yeast and metazoans.
  • To provide insights into kinetochore regulation in human health and disease.

Main Methods:

  • Literature review of existing studies on Ndc80 complex regulation.
  • Comparative analysis of molecular circuits controlling Ndc80 synthesis and degradation.
  • Synthesis of findings from budding yeast and metazoan meiosis.

Main Results:

  • Ndc80 complex subunit abundance is tightly regulated through protein synthesis and degradation.
  • Budding yeast meiosis provides a model system for understanding these regulatory circuits.
  • Significant conservation of regulatory principles between budding yeast and metazoans is proposed.

Conclusions:

  • The regulation of Ndc80 complex subunit abundance is critical for accurate chromosome segregation during meiosis.
  • Understanding these mechanisms in model organisms can inform research on human reproductive health and diseases.
  • Future research should focus on the conserved regulatory principles of kinetochore components.