Rectal Granular Cell Carcinoma Requiring Abdominoperineal Resection

Area of Science:

• Gastroenterology
• Surgical Oncology
• Pathology

Background:

• Granular cell tumors (GCTs) are rare neoplasms originating from neural crest cells.
• Colorectal GCTs are exceptionally uncommon, with limited documented cases in the medical literature.
• This report focuses on a GCT in the rectum with anal sphincter invasion.

Observation:

• A 56-year-old male presented with anal pain due to a perirectal mass.
• Ultrasound-guided transrectal biopsy confirmed a low-grade GCT.
• The patient underwent a laparoscopic abdominoperineal resection and perineum reconstruction.

Findings:

• Pathological analysis revealed a 4.5 cm GCT invading the anal sphincters.
• Despite a low-grade histological classification, the tumor exhibited aggressive behavior.
• Surgical margins were confirmed to be free of neoplastic tissue.

Implications:

• This is the first reported case of a colorectal GCT necessitating abdominoperineal resection.
• Further research into malignant GCTs is crucial for improved therapeutic strategies and patient outcomes.
• Long-term follow-up is essential to monitor for disease progression or metastasis.