Related Experiment Video
Updated: Jul 26, 2026
12:00
A Simplified Technique for Producing an Ischemic Wound Model
Published on: May 2, 2012
17.5K
Atypical Ulcerative Necrobiosis Lipoidica Diabeticorum: A Case Study
1Samaritan Medical Center, Watertown, NY, USA.
The International Journal of Lower Extremity Wounds
|March 22, 2021
Summary
Necrobiosis lipoidica diabeticorum (NLD) is a rare skin condition linked to diabetes. This case highlights doxycycline as a potential treatment when glucose control alone is insufficient for NLD improvement.
Area of Science:
- Dermatology
- Endocrinology
Background:
- Necrobiosis lipoidica is a granulomatous skin disease.
- Necrobiosis lipoidica diabeticorum (NLD) is a subtype associated with diabetes mellitus, affecting 0.3%-1.6% of diabetic patients.
- The etiology of NLD is unknown, and its treatment remains debated, particularly the role of glycemic control.
Purpose of the Study:
- To present a case study on the treatment of necrobiosis lipoidica diabeticorum (NLD).
- To investigate the efficacy of doxycycline in a patient with NLD unresponsive to improved glucose control.
Main Methods:
- Case report detailing a patient with NLD.
- Evaluation of treatment response to enhanced glucose control.
- Assessment of treatment efficacy following the introduction of doxycycline.
Main Results:
- The patient's NLD did not improve despite achieving better glycemic control.
- Introduction of doxycycline led to improvement in the patient's NLD condition.
Conclusions:
- Improved glucose control alone may not be sufficient for treating NLD.
- Doxycycline may represent a viable therapeutic option for NLD, warranting further investigation.
Related Concept Videos
01:26Type I Diabetes II: Pathophysiology
Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
01:19Type I Diabetes III: Clinical Manifestations
Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
01:22Diabetic Ketoacidosis ll: Pathophysiology
Diabetic ketoacidosis (DKA) is a metabolic emergency characterized by hyperglycemia, ketonemia, and metabolic acidosis. It results from severe insulin deficiency and an excess of counterregulatory hormones, leading to uncontrolled lipolysis, ketogenesis, and widespread electrolyte and fluid disturbances.Pathophysiology The central event in DKA is a profound loss of insulin action. Without insulin, glucose uptake in insulin-dependent tissues is impaired, while hepatic glucose production...
01:31Diabetic Foot Ulcer
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...