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Nail: News in Onychopathology.

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Related Experiment Video

Updated: Nov 12, 2025

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy
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Pathology of the Nail Unit.

Beth S Ruben1

  • 1Palo Alto Medical Foundation Medical Group, Dermatology, 795 El Camino Real, Clark Building, 2nd Floor, Palo Alto, CA 94301, USA.

Dermatologic Clinics
|March 22, 2021
PubMed
Summary

This review covers nail unit diseases, focusing on inflammatory, infectious, and neoplastic conditions. It highlights clinicopathologic correlations and diagnostic pitfalls to improve patient care.

Keywords:
MelanonychiaNail diseaseNail unit inflammatory diseaseNail unit neoplasmsNail unit pathologyOnychomycosisPsoriasis

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Area of Science:

  • Dermatopathology
  • Nail Unit Biology

Background:

  • Nail diseases encompass a wide range of conditions, including inflammatory, infectious, and neoplastic disorders.
  • Accurate histologic diagnosis is crucial for effective management.

Purpose of the Study:

  • To review the histopathologic findings in key nail unit diseases.
  • To emphasize clinicopathologic correlates and diagnostic best practices.

Main Methods:

  • Review of literature on nail unit histopathology.
  • Discussion of diagnostic pitfalls and best practices for biopsy interpretation.

Main Results:

  • Detailed description of histologic features for various nail diseases.
  • Identification of common diagnostic challenges and how to overcome them.

Conclusions:

  • Understanding nail unit pathology improves diagnostic accuracy.
  • Enhanced clinicopathologic correlation leads to better patient management and treatment strategies.