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Updated: Nov 12, 2025
A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice
Published on: December 18, 2015
Application of genetic cell-lineage tracing technology to study cardiovascular diseases
Xiaotong Sun1, Lingxia Lyu1, Xingxing Zhong1
1Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Insights
Lineage tracing reveals diverse cell origins in cardiovascular disease and repair. This technique tracks cell fates in vivo, offering insights into cellular plasticity and disease mechanisms.
Area of Science:
- Cardiovascular biology
- Cellular and molecular medicine
Background:
- Cardiovascular diseases (CVDs) are a major global health threat.
- Understanding cell behavior in CVD development and tissue repair is crucial.
- Various technologies aid in investigating cellular roles in cardiovascular health.
Purpose of the Study:
- To review the development of lineage tracing techniques.
- To summarize the application of lineage tracing in cardiovascular research.
- To highlight insights into cell origins and plasticity in CVDs.
Main Methods:
- Lineage tracing techniques allow in vivo tracking of cell fates.
- These methods provide insights into cellular behavior and plasticity.
- Applications in cardiac disease and vascular injury models are discussed.
Main Results:
- Newly formed cardiomyocytes and endothelial cells in cardiac disease arise from local proliferation.
- Fibroblasts and macrophages in cardiac disease originate from diverse sources.
- Vascular injury involves multiple cell sources including local progenitors and bone marrow cells.
Conclusions:
- Lineage tracing is a powerful tool for studying cell origins in cardiovascular contexts.
- Understanding cell plasticity is key to addressing cardiovascular diseases.
- This review consolidates current knowledge on lineage tracing in cardiovascular research.
Abstract:
Cardiovascular diseases are leading causes that threaten people's life. To investigate cells that are involved in disease development and tissue repair, various technologies have been introduced. Among these technologies, lineage tracing is a powerful tool to track the fate of cells in vivo, providing deep insights into cellular behavior and plasticity. In cardiac diseases, newly formed cardiomyocytes and endothelial cells are found from proliferation of local cells, while fibroblasts and macrophages are originated from diverse cell sources. Similarly, in response to vascular injury, various sources of cells including media smooth muscle cells, endothelium, resident progenitors and bone marrow cells are involved in lesion formation and/or vessel regeneration. In summary, current review summarizes the development of lineage tracing techniques and their utilizations in investigating roles of different cell types in cardiovascular diseases.
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