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Updated: Nov 12, 2025

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

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Published on: June 14, 2015

The Triple-Layer Patch Technique for Postinfarction Ventricular Septal Rupture.

Davide Pacini¹, Antonino Costantino², Mariafrancesca Fiorentino²

¹Division of Cardiac-Surgery, Istituto di Ricovero e Cura a Carattere Scientifico, Azienda-Ospedaliero-Universitaria di Bologna, Bologna, Italy; Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, University of Bologna, Bologna, Italy.

The Annals of Thoracic Surgery

|March 22, 2021

Summary

This summary is machine-generated.

Postinfarction ventricular septal rupture (VSR) is a serious heart complication. A new triple-layer patch technique effectively treated 8 patients, showing no residual shunts or rupture.

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Area of Science:

Cardiology
Cardiac Surgery
Mechanical Complications of Myocardial Infarction

Background:

Postinfarction ventricular septal rupture (VSR) is a critical mechanical complication following myocardial infarction.
VSR often leads to cardiogenic shock and carries high mortality rates.
Surgical repair of VSR is complex, with risks including cardiac rupture, bleeding, and residual shunts.

Purpose of the Study:

To present an innovative triple-layer patch technique for surgical correction of VSR.
To evaluate the efficacy and safety of this technique in a series of patients.
To address the observed increase in VSR cases during the COVID-19 pandemic.

Main Methods:

A consecutive series of 8 patients with VSR underwent surgical correction using a novel triple-layer patch.
The technique was specifically developed to mitigate risks associated with VSR repair.
Outcomes were assessed for residual shunts, cardiac rupture, and overall patient survival.

Main Results:

The triple-layer patch technique was successfully applied in all 8 patients.
No instances of residual shunt were observed post-surgery.
No cases of cardiac rupture or operative death occurred in the series.

Conclusions:

The innovative triple-layer patch technique is an effective and safe method for VSR repair.
This approach potentially reduces complications and improves outcomes in postinfarction VSR.
The technique offers a promising solution for managing this severe mechanical complication.