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Updated: Nov 12, 2025

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Published on: June 28, 2019
Outer Membrane Vesicles of Gram-Negative Bacteria: An Outlook on Biogenesis
Eric Daniel Avila-Calderón1,2, María Del Socorro Ruiz-Palma1,3, Ma Guadalupe Aguilera-Arreola1
1Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México City, Mexico.
Abstract:
Outer membrane vesicles (OMVs) from Gram-negative bacteria were first described more than 50 years ago. However, the molecular mechanisms involved in biogenesis began to be studied only in the last few decades. Presently, the biogenesis and molecular mechanisms for their release are not completely known. This review covers the most recent information on cellular components involved in OMV biogenesis, such as lipoproteins and outer membrane proteins, lipopolysaccharide, phospholipids, quorum-sensing molecules, and flagella.
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