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Updated: Nov 12, 2025
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
The Association of Glomerular Filtration Rate With Echocardiographic Parameters in Chronic Kidney Disease
Mahmut Ozdemir1, Ramazan Asoglu2, Zeki Dogan3
1Cardiology Department, School of Medicine, Istanbul Aydin University, Istanbul, Turkey.
Insights
Aortic propagation velocity (APV), epicardial fat thickness (EFT), and carotid intima-media thickness (CIMT) can predict kidney function decline in chronic kidney disease (CKD) patients. These markers may aid in managing CKD progression.
Area of Science:
- Nephrology
- Cardiology
- Medical Imaging
Background:
- Cardiovascular disease (CVD) is a leading cause of death in chronic kidney disease (CKD) patients.
- Aortic propagation velocity (APV), epicardial fat thickness (EFT), and carotid intima-media thickness (CIMT) may offer insights into renal decline.
- The study aimed to assess these parameters in CKD patients and their associations.
Purpose of the Study:
- To evaluate APV, EFT, and CIMT in patients with varying stages of CKD.
- To investigate the relationship between APV, EFT, CIMT, and estimated glomerular filtration rate (eGFR).
- To identify independent predictors of renal function in CKD patients.
Main Methods:
- 170 CKD patients were categorized into five groups based on eGFR.
- Transthoracic echocardiography was used to measure APV and EFT.
- CIMT was measured, and multivariate regression analysis was performed.
Main Results:
- APV decreased, while EFT and CIMT increased with CKD progression (P < 0.001).
- eGFR showed a positive correlation with APV and negative correlations with EFT and CIMT.
- APV, EFT, and CIMT were identified as independent predictors of eGFR.
Conclusions:
- APV, EFT, and CIMT change predictably with CKD progression.
- These vascular and cardiac fat markers could be valuable tools in routine CKD patient assessment.
- Integrating these measurements may improve the management of CKD patients.
Background:
Cardiovascular disease (CVD) is the primary cause of mortality and morbidity in chronic kidney disease (CKD) patients. Aortic propagation velocity (APV), epicardial fat thickness (EFT) and carotid intima-media thickness (CIMT) measurements could provide additional information on assessing renal decline in CKD patients. The study aimed to evaluate EFT, AVP and CIMT in CKD patients and then investigate the association among those parameters.
Methods:
A total of 170 CKD consecutive subjects were enrolled in the study. Patients were divided into five groups according to their estimated glomerular filtration rate (eGFR) values. Each patient underwent complete transthoracic echocardiography examination. APV, EFT and CIMT were measured for analyses. A multivariate linear regression model was used for analysis to determine the independent predictors of eGFR.
Results:
The lowest APV was observed in stage IV-V, and the highest APV was observed in stage I-II (P < 0.001). Stage IV-V patients had the highest EFT and stage I-II patients had the lowest EFT (P < 0.001). Moreover, the lowest CIMT was observed in stage III, and the highest CIMT was observed in stage V (P < 0.001). eGFR was significantly and positively correlated with APV and negatively correlated with EFT and CIMT. In multivariate analyses, APV (odds ratio (OR): 0.289, P < 0.001), EFT (OR: -0.135, P < 0.001) and CIMT (OR: -0.388, P < 0.001) were independent predictors of eGFR.
Conclusion:
We found that APV decreased, and EFT and CIMT increased as CKD progress. The present study suggests that APV, EFT and CIMT might be incorporated with the examination of CKD patients in daily practice.
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