Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Carbohydrate intolerance during complete fasting].

H Göschke, H Thölen

    Schweizerische Medizinische Wochenschrift
    |December 10, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evidence for X(3872) in Pb-Pb Collisions and Studies of its Prompt Production at sqrt[s_{NN}]=5.02  TeV.

    Physical review letters·2022
    Same author

    Development and validation of HERWIG 7 tunes from CMS underlying-event measurements.

    The European physical journal. C, Particles and fields·2021
    Same author

    Measurement of single-diffractive dijet production in proton-proton collisions at <math> </math> with the CMS and TOTEM experiments.

    The European physical journal. C, Particles and fields·2020
    Same author

    Evidence for Top Quark Production in Nucleus-Nucleus Collisions.

    Physical review letters·2020
    Same author

    A Deep Neural Network for Simultaneous Estimation of b Jet Energy and Resolution.

    Computing and software for big science·2020
    Same author

    Observation of the Production of Three Massive Gauge Bosons at sqrt[s]=13  TeV.

    Physical review letters·2020
    Same journal

    Respiratory function test in the case of temporary phrenic nerve contusion, associated with pneumoperitoneum; About the diagnostic value of laparoscopy.

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    Treatment of pulmonary tuberculosis and pleurisy by means of temporary paralysis of the diaphragm, supported by the pneumoperitoneum.

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    Boeck's disease as a tuberculous syndrome.

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    Enteral primary tubercular complexes

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    Tuberculous stenoses of the large bronchi.

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    About the enzyme action.

    Schweizerische medizinische Wochenschrift·2010
    See all related articles

    Fasting impairs glucose tolerance more in lean than obese individuals due to hormonal changes. Fructose metabolism is also affected by fasting, contrary to prior beliefs.

    Area of Science:

    • Metabolic research
    • Human physiology
    • Endocrinology

    Background:

    • Glucose tolerance can be affected by fasting and body composition.
    • Hormonal factors play a role in regulating glucose metabolism.
    • The impact of fasting on fructose metabolism is not fully understood.

    Purpose of the Study:

    • To investigate the differential effects of prolonged fasting on glucose tolerance in lean versus obese individuals.
    • To compare glucose and fructose tolerance after fasting in normal subjects.
    • To examine the metabolic response to fasting and substrate infusion.

    Main Methods:

    • Oral glucose tolerance tests (GTT) and insulin tolerance tests (ITT) were conducted on lean and obese non-diabetics before and after prolonged fasts (≥6 days).

    Related Experiment Videos

  • Plasma levels of glucagon, growth hormone, free fatty acids, and ketones were measured.
  • Glucose and fructose tolerance were assessed via 4-hour infusions in normal subjects before and after 4-day fasts.

    • Main Results:

    • Lean individuals showed greater glucose tolerance deterioration after fasting compared to obese individuals.
    • Fasting lean subjects had higher plasma glucagon, growth hormone, free fatty acids, and ketones than fasting obese subjects.
    • After fasting, both glucose and fructose infusions resulted in higher plasma hexose levels and delayed lactate/pyruvate rise, contradicting previous assumptions about unimpaired fructose metabolism.

    Conclusions:

    • Prolonged fasting disproportionately affects glucose tolerance in lean individuals, linked to hormonal changes and reduced insulin sensitivity.
    • Fasting impairs the body's ability to metabolize both glucose and fructose, challenging the notion of fructose's resilience during starvation.
    • These findings highlight the complex metabolic adaptations to fasting and suggest a need to re-evaluate fructose metabolism research.