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Long-term and quality of survival in patients treated for acute lymphoblastic leukemia during the pediatric age

Lara Devilli1, Chiara Garonzi1, Rita Balter1

  • 1Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.

Hematology Reports
|March 22, 2021
PubMed

Insights

Childhood acute lymphoblastic leukemia (ALL) survival is high, with survivors reporting good quality of life. Current ALL treatments are well-tolerated and do not significantly impact long-term well-being.

Area of Science:

  • Pediatric Oncology
  • Hematology
  • Clinical Research

Background:

  • Childhood acute lymphoblastic leukemia (ALL) survival rates have significantly improved over the past 30 years, reaching 80-90%.
  • Focus is shifting towards the quality of life for childhood ALL survivors.

Purpose of the Study:

  • To analyze the clinical features and outcomes of 119 children with ALL.
  • To specifically evaluate the long-term quality of life in a subset of 22 adult survivors (over 18 years old).

Main Methods:

  • Retrospective analysis of clinical data for 119 pediatric ALL patients.
  • Detailed assessment of long-term outcomes and quality of life in 22 adult survivors.

Main Results:

  • The 10-year event-free survival was 83.1% and overall survival was 88.4% in the adult survivor group.
  • Only 9.1% of survivors reported treatment-related long-term medical complications.
  • 89.9% of survivors successfully completed secondary education.

Conclusions:

  • Current pediatric ALL treatments are well-tolerated.
  • Long-term survival for childhood ALL does not significantly compromise survivors' quality of life.
  • High rates of educational attainment indicate positive long-term outcomes.

Keywords:
acute lymphoblastic leukemiapediatric leukemiasurvival

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