Related Experiment Video

Updated: Nov 12, 2025

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

2.7K

Distinct Characteristics of COVID-19 Infection in Children

Xuejiao Han1, Xuemei Li2, Yinan Xiao3

  • 1Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in Pediatrics
|March 22, 2021
PubMed

Insights

Children are susceptible to COVID-19 (coronavirus disease 2019) and often present mild symptoms. This review summarizes COVID-19 in pediatric patients, highlighting the need for better understanding and management strategies.

Area of Science:

  • Virology and Epidemiology
  • Pediatric Infectious Diseases

Background:

  • The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has significantly impacted global health.
  • Pediatric cases of COVID-19 (coronavirus disease 2019) are increasingly recognized, though less studied than adult cases.
  • Children infected with SARS-CoV-2 often exhibit milder symptoms or remain asymptomatic, complicating diagnosis and management.

Purpose of the Study:

  • To conduct a literature review on pediatric COVID-19 (coronavirus disease 2019) cases.
  • To summarize current knowledge on the pathogenesis, epidemiology, and clinical management of COVID-19 in patients under 18 years old.
  • To enhance understanding of SARS-CoV-2 infection in the pediatric population.

Main Methods:

  • Literature review of studies published in PubMed and medRxiv (preprints).
  • Inclusion criteria: Papers published between December 2019 and December 2020.
  • Focus on studies reporting confirmed COVID-19 diagnoses in pediatric patients (aged below 18 years).

Main Results:

  • Pediatric COVID-19 (coronavirus disease 2019) cases are often linked to household clusters or exposure to endemic areas.
  • Common symptoms in children include fever, cough, and fatigue, generally milder than in adults.
  • Laboratory and radiological findings in pediatric patients are frequently non-specific.

Conclusions:

  • Data on pediatric COVID-19 (coronavirus disease 2019) remains limited compared to adult populations.
  • No specific antiviral treatments are currently approved for children, emphasizing the importance of preventive measures.
  • Further research is crucial to improve the understanding and clinical management of SARS-CoV-2 in pediatric patients.

Keywords:
COVID-19SARS-C0V-2characteristicschildreninfectionpediatrics

More Related Videos

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia08:05

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

14.4K
Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.5K

Related Concept Videos

Stages of Infection01:26

Stages of Infection

Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
62.0K
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
114
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.0K
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
92
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
85
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
531