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Madelung disease: A case report.

Ke-Ke Chen1, Lian-Song Ni1, Wei-Hui Yu2

  • 1Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.

World Journal of Clinical Cases
|March 22, 2021
PubMed
Summary
This summary is machine-generated.

Madelung disease (MD) is a rare fat metabolism disorder causing excess adipose tissue. This case report details an MD patient with type 2 diabetes, highlighting disease awareness.

Keywords:
Case reportDiabetesMadelung diseaseMultiple lipomatosis

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Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Rare Diseases

Background:

  • Madelung disease (MD) is a rare disorder characterized by abnormal adipose tissue deposition.
  • It affects the superficial fascial spaces of the head, neck, and shoulders.

Observation:

  • A 61-year-old Chinese male with a history of smoking and alcohol abuse presented with progressive fat deposition.
  • Symptoms included excess fat in the mandible, neck, abdomen, and elbows.
  • Ultrasonic and CT scans confirmed diffuse fat deposition in the neck's subcutaneous fascia.

Findings:

  • The patient was diagnosed with Madelung disease.
  • The case was complicated by type 2 diabetes.
  • MD diagnosis was supported by imaging findings of subcutaneous adipose tissue accumulation.

Implications:

  • This case underscores the importance of recognizing Madelung disease, especially in patients with metabolic comorbidities like type 2 diabetes.
  • Understanding MD pathogenesis, diagnosis, and treatment is crucial for clinicians.
  • Raising clinical awareness can lead to earlier diagnosis and better management of MD.