Related Experiment Video For Benign
Updated: Nov 12, 2025
Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
Doppelgänger dilemma: Leiomyoma versus uveal melanoma
Ankit Singh Tomar1, Anthony Fam1, Paul T Finger1,2
1Department of Ocular Tumor and Orbital Disease, The New York Eye Cancer Center, New York, NY, USA.
Background:
Ciliary body tumors can remain undetected and achieve large dimensions. Pigmented ciliary body tumors include: melanoma, leiomyoma and melanocytoma, however correct diagnosis may require tissue diagnosis with immunohistochemical stains.
Case Presentation:
Two men presented with identical ciliochoroidal tumors. Both had darkly pigmented dome-shaped anterior uveal masses, exudative retinal detachments and transillumination shadowing. Ocular PET-CT imaging revealed that both were metabolically active consistent with a diagnosis of cancer. However, immunohistochemical examination revealed one a leiomyoma and the other melanoma.
Conclusion:
Uveal leiomyoma can be an indistinguishable doppelgänger to ciliochoroidal melanoma, where the diagnosis can only be established by immunohistopathology.
