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Updated: Nov 12, 2025
Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System
Published on: June 13, 2010
Magnetic Microdevices for MRI-Based Detection of SARS-CoV-2 Viruses
Lamar O Mair1, Olivia Hale1, Sahar Jafari2
1Neuroparticle Corporation, North Bethesda, MD, USA.
Goal:
To develop a micron-scale device that can operate as an MRI-based reporter for the presence of SARS-CoV-2 virus.
Methods:
Iron rod microdevices were constructed via template-guided synthesis and suspended in phosphate buffered saline (PBS). Heat-inactivated SARS-CoV-2 viruses were added to the samples and imaged with low-field MRI.
Results:
MRI of microdevices and viruses showed decreased signal intensity at low concentrations of viruses that recovered at higher concentrations. Electron micrographs suggest that reduced MRI intensity may be due to concentration-dependent shielding of water protons from local magnetic inhomogeneities caused by the iron microdevices.
Conclusions:
The preliminary results presented in this letter provide justification for further studies exploring the potential diagnostic role of magnetic microdevices in assessing the presence and concentration of SARS-CoV-2 viruses.
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