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Early Insights into COVID-19 in Persons Living with HIV and Cardiovascular Manifestations

Jelani K Grant1, Louis Vincent1, Bertrand Ebner1

  • 1Department of Medicine, University of Miami Miller School of Medicine/Jackson Memorial Hospital, Miami, Florida, USA.

Journal of AIDS and HIV Treatment
|March 22, 2021
PubMed

Insights

People with HIV-1 (PLHIV) face higher cardiovascular risks. This review examines if COVID-19 worsens cardiovascular issues in PLHIV, considering the combined inflammatory effects.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Immunology

Background:

  • Persons living with HIV-1 (PLHIV) have a persistent inflammatory state increasing cardiovascular complication risk, even with viral suppression.
  • SARS-CoV-2 (COVID-19) infection causes acute cardiovascular complications due to its associated inflammatory response.
  • The impact of COVID-19 on cardiovascular health in PLHIV is not yet fully understood.

Purpose of the Study:

  • To review and consider the potential for exacerbated cardiovascular manifestations in individuals coinfected with HIV-1 and COVID-19.

Main Methods:

  • This study is a review of existing literature and research.
  • Analysis of the combined effects of HIV-1 and SARS-CoV-2 on cardiovascular health.
  • Consideration of inflammatory pathways in coinfection.

Main Results:

  • HIV-1 infection is associated with increased cardiovascular risk due to chronic inflammation.
  • COVID-19 triggers acute cardiovascular complications via inflammation.
  • The synergistic effect of coinfection on cardiovascular outcomes requires further investigation.

Conclusions:

  • Coinfection with HIV-1 and COVID-19 may lead to more severe cardiovascular complications.
  • Understanding these combined effects is crucial for managing coinfected individuals.
  • Further research is needed to elucidate the specific risks and mechanisms involved.

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