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Updated: Nov 12, 2025

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
[ALLERGY PREVENTION AND TREATMENT DURING THE FIRST YEAR]
Ron Shaoul1, Miri Pevzner2, Zehavit Goldshtein3
1Pediatric Gastroenterology Institute, Ruth Children's Hospital, Rambam Medical Center., Faculty of Medicine, Technion.
Insights
Exclusive breastfeeding for six months is recommended for infant allergy prevention. For non-breastfed infants at risk, hydrolyzed formulas may reduce allergy risk, while soy formulas are not recommended. Early introduction of solids is advised.
Area of Science:
- Pediatrics
- Allergology
- Immunology
Background:
- Maternal and infant nutrition significantly impacts allergy development.
- Recent research guides infant feeding recommendations for allergy prevention.
- Established guidelines exist for at-risk infants, including those with a family history of allergies.
Purpose of the Study:
- To summarize current evidence-based recommendations for infant feeding and allergy prevention.
- To inform healthcare professionals on managing infant nutrition for atopic disease risk.
- To highlight changes in clinical practice regarding infant feeding and allergen exposure.
Main Methods:
- Review of recent scientific literature and clinical guidelines.
- Analysis of recommendations from European and United States healthcare bodies.
- Synthesis of data on breastfeeding, hydrolyzed formulas, soy formulas, and solid food introduction.
Main Results:
- Exclusive breastfeeding for 6 months is recommended for all infants.
- Partially or fully hydrolyzed formulas may benefit non-breastfed infants at high risk of allergies.
- Early introduction of solids (4-6 months) without allergen avoidance is recommended; delayed introduction may increase allergy risk.
Conclusions:
- Current guidelines emphasize exclusive breastfeeding and early introduction of diverse solids.
- Hydrolyzed formulas are a viable option for specific high-risk, non-breastfed infants.
- Healthcare providers must stay updated on evolving infant nutrition and allergy prevention strategies.
Introduction:
The effect of the pregnant mother's nutrition and the effect of the baby's nutrition during the first-year on the development of allergy and atopic disease in the baby have been studied extensively in recent years. Key recommendations for healthcare bodies in Europe and the United States include: • Allergy prevention in at-risk infants (parent or sibling with allergy): Currently, there is a consensus of healthcare organizations around the world that the recommended exclusive breastfeeding duration is the first 6 months of life for the overall health benefit of the baby. Allergy prevention in non-breastfed infants at risk: There are studies showing that fully hydrolyzed formula can reduce the risk of allergic reactions, especially atopic dermatitis, in high-risk non-breastfed babies. Some recommendations for high-risk non-breastfed infants support feeding up to 4 to 6 months with hydrolyzed formulas. Further research is needed on this subject. Soy formulas failed to prevent allergy in high-risk infants. • In case of cow's milk allergy symptoms in breastfed babies: Although a small amount of food allergens may be present in the milk, mothers should be encouraged to continue breastfeeding while avoiding consumption of cow's milk and products. • In case of cow's milk allergy symptoms in non-breastfed babies: Under six months of age, extensively hydrolyzed formula is suitable for most cases of cow's milk allergy, except for severe clinical conditions, which require amino acid formulas. Over six months, soy formulas can be considered. Exposure to solid foods: The current recommendations are to start on solids at the age of 4-6 months and there is no recommendation for avoiding known allergens, despite family history. Later introduction of peanut, fish or egg does not prevent, and may even increase, the risk of developing food allergy. In order to provide a professional and appropriate response to infants and parents, it is important to know the latest guidelines, based on research from recent years as clinical recommendations have changed over the past few decades.
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