Social epigenomics: are we at an impasse?

Area of Science:

• Social epigenomics
• Genetics
• Public Health

Background:

• Social scientists expect epigenomics to explain links between adverse social factors (poverty, racism) and complex diseases.
• Progress in social epigenomics is hindered by challenges similar to genomics: overhype, limited sample diversity, replication issues, and interpretation difficulties.

Purpose of the Study:

• To review the progress and challenges in social epigenomics.
• To propose future directions and recommendations for the field.

Main Methods:

• Literature review focusing on social epigenomics.
• Discussion of methodological and analytical challenges.
• Synthesis of recommendations for future research.

Main Results:

• Identified key challenges including lack of sample diversity, limited replication, and interpretation difficulties.
• Highlighted the need for cross-cultural, longitudinal, and multi-generational studies.
• Emphasized the necessity for increased data accessibility and interdisciplinary collaboration.

Conclusions:

• Social epigenomics holds promise but requires overcoming significant hurdles.
• Future advancements depend on diverse samples, robust methodologies, and integrated data approaches.
• Enhanced collaboration between social scientists and geneticists is crucial for advancing the field.