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Is Adoptive Cellular Therapy With Non-T-Cell Immune Effectors the Future?
Alaa Kassim Ali1, Mubin Tarannum, Rizwan Romee
1From the Cellular Therapy and Stem Cell Transplant Program, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA.
Cancer Journal (Sudbury, Mass.)
|March 22, 2021
Summary
Chimeric antigen receptor T cells show promise in cancer immunotherapy but have limitations. Exploring innate immune cells like natural killer cells offers a promising alternative for adoptive cell therapy and engineering.
Area of Science:
- Immunology
- Oncology
- Cell Therapy
Background:
- Checkpoint blockade and adoptive cell therapy have advanced cancer immunotherapy.
- Chimeric antigen receptor (CAR) T cells are effective against liquid tumors but cause severe side effects and graft-versus-host disease.
- Limitations necessitate exploring alternative cell types for adoptive cell therapy.
Purpose of the Study:
- To provide an overview of innate immune cells for adoptive cell therapy.
- To explore the potential of innate immune cells in chimeric antigen receptor engineering.
- To highlight alternative strategies for cancer immunotherapy.
Main Methods:
- Review of current literature on adoptive cell therapy.
- Analysis of innate immune cell functions and potential for CAR engineering.
- Discussion of challenges and future directions in innate cell-based immunotherapy.
Main Results:
- Innate immune cells, including natural killer cells, macrophages, natural killer T cells, and γδ T cells, possess potential for adoptive cell therapy.
- CAR engineering can enhance the anti-tumor activity of these innate immune cells.
- These cells may offer advantages over T cells in certain contexts.
Conclusions:
- Innate immune cells represent a promising alternative for adoptive cell therapy in cancer treatment.
- Further research into CAR-engineered innate immune cells could overcome limitations of current therapies.
- Exploring innate immunity is crucial for advancing cancer immunotherapy.
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