Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Unsymmetric Bending - Angle of Neutral Axis01:15

Unsymmetric Bending - Angle of Neutral Axis

626
Unsymmetrical bending occurs when a structural member is subjected to bending moments in a plane that does not align with the member's principal axes. This scenario typically arises in beams and other structural components when loads are applied at non-ideal angles, introducing complexities in stress analysis.
When a bending moment is applied at an angle θ concerning the vertical axis of a symmetrical member, it can be resolved into components along the member's principal...
626
Nondisjunction01:29

Nondisjunction

79.3K
During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
79.3K
Nondisjunction01:21

Nondisjunction

4.4K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
4.4K
Unsymmetric Bending01:18

Unsymmetric Bending

608
Unsymmetrical bending occurs when the bending moment applied to a structural member does not align with its principal axis. This misalignment leads to complex stress distributions and deflection patterns that differ from those in symmetrical bending, and are essential for designing structures to withstand different loading conditions. In unsymmetrical bending, the neutral axis—where stress is zero—does not necessarily align with the geometric axes of the cross-section. The...
608
Alternative RNA Splicing02:18

Alternative RNA Splicing

23.6K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
23.6K
Multiple Allele Traits01:49

Multiple Allele Traits

36.6K
The Concept of Multiple Allelism
36.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Rare Portopulmonary Arteriovenous Fistula in a Cirrhotic Patient With Portal Hypertension and Inversion of Blood Flow After Liver Transplantation.

The American journal of gastroenterology·2022
Same author

Case 306: Ectopic Thyroid Goiter in the Porta Hepatis.

Radiology·2022
Same author

Case 305: Loeffler Endocarditis.

Radiology·2022
Same author

Case 306.

Radiology·2022
Same author

Case 305.

Radiology·2022
Same author

Adult-type Anomalous Origin of the Left Coronary Artery from the Pulmonary Artery.

Radiology·2021
Same journal

Erratum for: Prediction of Lobar Emphysema Progression with a CT-Based Foundational Model.

Radiology·2026
Same journal

Erratum for: Associations of MRI-derived Paraspinal IMAT and LMM with Cardiometabolic Risk Factors: Results from a German Cohort.

Radiology·2026
Same journal

Erratum for: Blue Rubber Bleb Nevus Syndrome.

Radiology·2026
Same journal

Redefining the Clinical Role of MRI in Endometrial Cancer Staging.

Radiology·2026
Same journal

To Ablate or Not to Ablate: The Colorectal Liver Metastasis Question.

Radiology·2026
Same journal

The Limits of Radiologic Categorization in Pulmonary Nonsolid Nodules.

Radiology·2026
See all related articles

Related Experiment Video

Updated: Nov 12, 2025

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
06:59

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation

Published on: February 29, 2020

8.5K

Case 288: Uhl Anomaly.

Settimo Caruso1, Christine Cannataci1, Giuseppe Romano1

  • 1From the Department of Diagnostic and Therapeutic Services (S.C.), and Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, Cardiology Unit (G.R.), Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS-ISMETT), Via Ernesto Tricomi 5, 90127 Palermo, Italy; and Department of Radiology, Mater Dei Hospital, Msida, Malta (C.C.).

Radiology
|March 22, 2021
PubMed
Summary
This summary is machine-generated.

This case study highlights a 46-year-old woman with a history of syncope and congestive heart failure, ultimately diagnosed with severe right ventricular dilation and massive tricuspid regurgitation. Advanced imaging confirmed significant cardiac abnormalities, guiding management toward heart transplantation evaluation.

More Related Videos

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA
13:10

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA

Published on: April 24, 2017

18.8K
Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

3.9K

Related Experiment Videos

Last Updated: Nov 12, 2025

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
06:59

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation

Published on: February 29, 2020

8.5K
Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA
13:10

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA

Published on: April 24, 2017

18.8K
Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

3.9K

Area of Science:

  • Cardiology and Cardiovascular Imaging
  • Adult Congenital Heart Disease
  • Heart Failure Pathophysiology

Background:

  • A 46-year-old woman presented with decompensated congestive heart failure and pericardial effusion.
  • She had a history of recurrent, non-exercise-related syncope since childhood, with no family history of sudden cardiac death.
  • Initial echocardiography revealed normal left ventricular function but significant right ventricular dilation without outflow tract obstruction.

Observation:

  • Clinical examination showed elevated venous pressure, normal peripheral pulses, and mild hypotension.
  • Electrocardiography indicated sinus rhythm, right bundle branch block, and right atrial dilatation.
  • Cardiac MRI quantified severe right ventricular dilation (RVDV/BSA: 164 mL/m²) with a markedly reduced ejection fraction (24%) and massive tricuspid regurgitation (46 mL).

Findings:

  • Advanced imaging, including MRI and CT, ruled out pulmonary embolism and confirmed severe right ventricular dysfunction.
  • Left ventricular ejection fraction was preserved (47%), but systemic output was diminished relative to pulmonary output.
  • The patient's complex cardiac anatomy precluded implantable cardioverter-defibrillator implantation, necessitating conservative management and evaluation for heart transplantation.

Implications:

  • This case underscores the importance of comprehensive cardiac imaging in diagnosing and managing complex right ventricular pathology.
  • Understanding the long-term sequelae of pediatric cardiac events is crucial for adult cardiology care.
  • The findings highlight the challenges in managing heart failure secondary to severe right ventricular dilation and tricuspid regurgitation.