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Updated: Nov 12, 2025
Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
Published on: February 16, 2022
Antibody kinetics and clinical course of COVID-19 a prospective observational study
Anna Bläckberg1,2, Nils Fernström1, Emma Sarbrant1
1Division of Infection Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Background:
Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19.
Materials And Methods:
A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed.
Results:
Forty patients with COVID-19, hospitalized at Skåne University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after confirmed COVID-19. Patients with severe COVID-19 had higher levels of antibodies directed against SARS-CoV-2 spike protein compared with patients with mild disease.
Conclusion:
IgG and IgA antibodies towards the spike protein follow different kinetics during COVID-19 and patients with severe disease develop higher antibody levels.
