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Updated: Nov 11, 2025

Expression and Purification of Virus-like Particles for Vaccination
06:17

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

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Fungal vaccines

H T Pattison1, B C Millar1,2, J E Moore1,2

  • 1School of Medicine, Dentistry and Biomedical Sciences, the Wellcome-Wolfson Institute for Experimental Medicine, Queen's University, Belfast, Northern Ireland, UK.

British Journal of Biomedical Science
|March 22, 2021
PubMed

Insights

Antifungal resistance threatens treatment of invasive fungal disease. This review explores novel fungal vaccine strategies, focusing on Aspergillus antigens and techniques for immunocompromised patients.

Area of Science:

  • Mycology
  • Immunology
  • Vaccinology

Background:

  • Invasive fungal infections pose significant life-threatening risks, especially in immunocompromised individuals with hematological malignancies.
  • Current antifungal drugs (azoles, echinocandins, polyenes) face emerging resistance, mirroring antibiotic resistance.
  • Developing effective fungal vaccines is crucial, but eliciting adequate immune responses in vulnerable populations remains a challenge.

Purpose of the Study:

  • To review current data on invasive fungal diseases and antifungal resistance.
  • To investigate potential Aspergillus antigens for vaccine development.
  • To explore feasible vaccine techniques for high-risk, immunocompromised populations.

Main Methods:

  • Literature review of recent data on fungal infections and antifungal resistance.
  • Assessment of potential Aspergillus antigens for immunogenicity.
  • Evaluation of vaccine delivery methods suitable for immunocompromised individuals.

Main Results:

  • Antifungal resistance is an increasing threat to treating invasive fungal infections.
  • Identifying suitable Aspergillus antigens is key for vaccine efficacy.
  • Adapting vaccine techniques is necessary for successful immunization of immunocompromised groups.

Conclusions:

  • Fungal vaccines offer a promising alternative to antifungal drugs, especially given rising resistance.
  • Targeting Aspergillus with novel vaccine strategies is essential for protecting high-risk groups.
  • Further research into vaccine techniques is needed to overcome challenges in immunocompromised patients.
Keywords:
AspergillusCFantifungal resistanceantimicrobial resistancefungal vaccineshaematological malignancy

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