Related Experiment Video
Updated: Nov 11, 2025
08:58
Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood
Published on: April 16, 2016
10.8K
Hemocompatibility of polyzwitterion-modified titanium dioxide nanotubes
Erna Jia1,2, Bang Liang1,2, Yuan Lin1
1The State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.
Nanotechnology
|March 22, 2021
Summary
Titanium dioxide nanotubes (TNTs) modified with zwitterionic polymers show excellent protein resistance and blood compatibility. These enhanced TNTs reduce protein adsorption and platelet activation, making them promising for implantable materials.
Area of Science:
- Biomaterials Science
- Surface Chemistry
- Nanotechnology
Background:
- Titanium dioxide nanotubes (TNTs) are promising implantable materials.
- Their blood compatibility is a significant challenge for biomedical applications.
Purpose of the Study:
- To improve the blood compatibility of TNTs.
- To investigate the protein resistance of zwitterionic polymer-coated TNTs.
Main Methods:
- Grafting poly(sulfobetaine methacrylate) (pSBMA) and poly(carboxybetaine methacrylate) (pCBMA) onto TNTs using ARGET-ATRP.
- Assessing protein adsorption (BSA, fibrinogen) and conformation (FT-IR).
- Evaluating hemocompatibility through hemolytic activity and platelet adhesion/activation tests.
Main Results:
- Zwitterionic polymer coatings significantly reduced protein adsorption on TNTs.
- Surface topography effects on protein adsorption were minimized by the coatings.
- Polyzwitterion-modified TNTs exhibited non-hemolytic properties and reduced platelet adhesion and activation.
Conclusions:
- Zwitterionic polymer modification greatly enhances the blood compatibility of TNTs.
- These modified TNTs show excellent protein resistance and reduced thrombogenicity.
- The developed materials hold potential for advanced biomedical implant applications.
