Pediatric Keratoconus in A Tertiary Eye Center in Alexandria: A Cross-sectional Study

To describe the clinical presentation, risk factors, and treatment choices documented in a pediatric keratoconus population treated at a tertiary referral center in Alexandria, Egypt.

: A cross-sectional study of 80 patients with keratoconus aged 18 years or younger referred to the cornea clinic at the Alexandria University Main Hospital between July 2018 and October 2019 was included. Patients' history, initial presentation, best spectacle corrected visual acuity (BSCVA), clinical signs, topographic data, and treatment were recorded.

Thirty patients were younger than 14 years and 50 were 14 years or older. Elements of the initial presentation included decreased vision in 26 patients, itching in 20 patients, both visual impairment and itching in 16 patients, accidental discovery during vision screening at school in 15 patients, and hydrops in three patients. All patients had bilateral keratoconus, except for four patients who had previously been treated by keratoplasty (n = 156 eyes). The mean logMAR BSCVA was 0.79 ± 0.63. The mean of the average keratometry (AveK), maximum keratometry (Kmax), central corneal thickness (CCT) and thinnest pachymetry reading were 51.16 ± 7.31 D, 59.18 ± 10.38 D, 458.44 ± 55.87 µ 440.08 ± 60.18 µ, respectively. 57 eyes (36%) had stage 1 disease, 43 eyes (28%) had stage 2 disease, 17 eyes (11%) had stage 3 disease and 39 eyes (25%) had stage 4 disease, respectively. No statistically significant differences in the LogMAR BSCVA, keratometry values, CCT, thinnest pachymetry reading, and the Amsler-Krumeich (AK) staging existed between the two age groups or between boys and girls. Crosslinking was indicated in 69 eyes (44%), while keratoplasty was the only viable solution for 39 eyes (25%), with three patients requiring keratoplasty in both eyes.

Keratoconus in children can result in severe loss of vision. Keratoconus screening programs in elementary schools should be considered in populations with a high incidence of keratoconus for early detection and adequate intervention.