Related Experiment Video
Updated: Nov 11, 2025

Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology
Published on: February 25, 2022
Pituitary stem cells
Naomi Even-Zohar1, Derya Metin Armagan1, Shlomo Melmed1
1Pituitary Center, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Abstract:
The anterior pituitary is derived from Rathke's pouch precursors, which differentiate into specific hormone-secreting cell lineages. Sustained low postnatal and adult pituitary cell turnover is governed by stem/progenitor cells that undergo slow mitotic activity and give rise to hormone-secreting cells in response to physiological demands and feedback loops. Pituitary cell populations exhibit stem cell properties, which include stem cell marker expression, non-hormone expression, and the ability to self-renew and to potentially differentiate into any of five hormone-secreting cell lineages. Specific signaling pathways underlie differentiated pituitary cell development and regulation. Several validated pituitary stem cell models have been reported and have the potential for functional regeneration of pituitary hormone-secreting cell functions.
More Related Videos
Related Concept Videos
Stem Cell Niche
Source And Potency Of Stem Cells
Multipotency of Hematopoietic Stem Cells
Multipotency and Niche of Bulge Stem Cell
Stem Cell Culture
Induced Pluripotent Stem Cells

