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Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Related Experiment Video

Updated: Nov 11, 2025

Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology
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Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology

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Pituitary stem cells.

Naomi Even-Zohar1, Derya Metin Armagan1, Shlomo Melmed1

  • 1Pituitary Center, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Vitamins and Hormones
|March 23, 2021
PubMed
Summary

Anterior pituitary stem cells self-renew and differentiate into hormone-secreting cells. These stem/progenitor cells are crucial for pituitary cell turnover and potential regeneration.

Area of Science:

  • Endocrinology
  • Developmental Biology
  • Stem Cell Biology

Background:

  • The anterior pituitary originates from Rathke's pouch precursors, differentiating into hormone-secreting cell types.
  • Pituitary cell populations possess stem cell properties, including self-renewal and differentiation potential.
  • Low postnatal and adult pituitary cell turnover is maintained by slow-dividing stem/progenitor cells.

Purpose of the Study:

  • To elucidate the role of pituitary stem/progenitor cells in maintaining anterior pituitary function.
  • To explore the self-renewal and differentiation capabilities of pituitary stem cells.
  • To understand the signaling pathways regulating pituitary cell development and regeneration.

Main Methods:

  • Characterization of pituitary stem cell markers and properties.
Keywords:
Cell therapyPituitary differentiationPituitary progenitors

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  • Investigation of stem/progenitor cell mitotic activity and lineage commitment.
  • Analysis of signaling pathways involved in pituitary cell differentiation.

    • Main Results:

    • Pituitary stem cells express specific markers, do not secrete hormones, and can self-renew.
    • These cells differentiate into multiple hormone-secreting lineages in response to physiological cues.
    • Validated models of pituitary stem cells demonstrate potential for functional regeneration.

    Conclusions:

    • Pituitary stem/progenitor cells are essential for sustained pituitary cell turnover and hormone production.
    • Understanding pituitary stem cell biology offers avenues for regenerative therapies.
    • Signaling pathways are critical regulators of pituitary stem cell fate and function.