Ten-Year Mortality in Patients With ST-Elevation Myocardial Infarction

Area of Science:

• Cardiology
• Clinical Medicine
• Interventional Cardiology

Background:

• Long-term outcomes and mortality predictors following primary percutaneous coronary intervention (p-PCI) for ST-elevation myocardial infarction (STEMI) remain incompletely understood.
• Existing data often lacks extended follow-up beyond 10 years, limiting knowledge of chronic phase prognosis.

Purpose of the Study:

• To evaluate the long-term prognosis, specifically 10-year all-cause mortality, in patients with STEMI who underwent p-PCI.
• To identify independent predictors of long-term mortality in this patient cohort.

Main Methods:

• A retrospective analysis of 459 consecutive STEMI patients treated with p-PCI between January 2006 and December 2010.
• The primary endpoint was 10-year all-cause mortality, assessed using Cox multivariate regression analysis.

Main Results:

• The cumulative 10-year incidence of all-cause death was 23.8%, indicating a 76.2% survival rate.
• Independent predictors of mortality included age ≥ 65 years, lower ejection fraction (<40%), presence of atrial fibrillation, hypoalbuminemia (<3.5 g/dL), and use of mineralocorticoid receptor antagonists.

Conclusions:

• STEMI patients undergoing p-PCI have a substantial long-term survival rate, but specific risk factors predict mortality.
• Identifying these predictors allows for targeted interventions and improved risk stratification for long-term STEMI patient management.